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OneLife SA
Avenue Albert Einstein 15
    1348 Louvain-la-Neuve
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  To summarise, the most important comparison points for enzymatic detergents are the following:

  • The types of enzymes  used that will determine which types of organic matter are broken down.  OneLife’s high-level detergents break down protein-based soil as well as the matrix of different bacterial biofilm (formed by different species).  In our published tests of 11 different Medical Device detergents, we are the only detergent (enzymatic and non-enzymatic) to break down biofilm of all 5 different species tested.  In order to achieve this, our detergents contains different types of protease and polysaccharidases, as well as lipase and laccase.  Within each enzyme “family”, such as protease and polysaccharidase, there are different types available that need to be selected carefully by the manufacturer in order to target the desired polymers.  OneLife’s multi-enzymatic formula with biofilm treatment is protected by a patent.
  • The quantity of enzymes , or the concentration, will also naturally impact the detergent efficacy.  OneLife’s detergents contain very high levels of enzymes; particularly enziQure. The concentration of enzymatic activity in our detergent is up to 50 times higher compared to other enzymatic detergents on the market. Enzyme concentration in a detergent is not a piece of information that can be found on a technical data sheet or a safety data sheet making it complicated to compare detergents.
  • How the enzymes are formulated  will also have a strong influence on the efficacy (enzymatic activity and stability).  OneLife’s ability to formulate enzymes is built on the 25 years’ experience of our parent company, Realco. The approach of traditional chemicals manufacturers is often to simply add some enzymes to their chemical formula. This approach can lead to enzyme destabilization and loss of enzymatic activity in the product.  OneLife’s approach is to start with the enzymes and to add the appropriate surfactants that we know are complementary to the enzymes and appropriate for the particular application. In this way, there is a synergy between enzymes and surfactants. Surfactants help the enzymes penetrate the soil and biofilms and the enzymes solubilize soil and biofilm by degrading the polymers into small, soluble compounds. The result is a complete degradation of soil and a physical release and elimination of the microorganisms trapped in biofilms, exposing them to disinfectants. 


    The only real way to demonstrate efficacy is through performance testing.  For the reasons described above, the arguments regarding the number of enzymes are not necessarily an indication as to the quality of the detergent.


TASS can be caused by the presence of microbial endotoxins (bacterial components originating from Gram-negative bacteria) on ophthalmic instruments. These compounds induce a pathological reaction that can lead to the loss of one eye.Endotoxins can come from water as cleaners (all types of products are at risk, not just enzymatic) but are not destroyed by sterilization. It is therefore crucial to apply heavy rinses with deionized water (and not mains water or softened water that may also contain endotoxins) to remove endotoxins prior to sterilization.With regard to enzymatic detergents in particular, the cases of TASS associated with this type of detergent have been caused by improper use of the products or incomplete rinsing of the instruments. A recent article by Lawrence Muscarella (2018) states that if enzymatic detergents could be a risk factor for TASS, in no case can enzymatic detergents be considered as a leading cause of TASS.


Extract from the article :  While the improper cleaning of intra- ocular instruments is recognized as a risk factor for TASS, this review found, however, that using an enzymatic deter- gent to clean intraocular instruments has not been shown to be either the primary cause of TASS or a more significant contributor to this inflammatory reaction of the eye than other documented risk factors, such as bacterial contamination of the water reservoirs of steam sterilizers, short-cycle sterilization, and damage to the intraocular instruments. More research is recommended to better quantify the relative risk of enzymatic detergents causing TASS, compared to these other risk factors, and to develop additional mitigations validated for the prevention of TASS. 



PRIONS (neurochirurgie) : 

OneLife detergents have not been tested according to the standard French prions protocol nor according to the German homonymous protocol. In general, although enzymes can degrade certain prion strains, no neutral enzymatic detergent has (as of September 2019) been prionicidal. The most commonly approved detergents for this are alkaline detergents, used at high concentrations, contact times and temperatures.


For information, the new version of the protocol prions 2018 in France (which will be in force in 2021) has become more stringent by asking for efficiency on several strains of prions. It is expected that several detergents / disinfectants that had been approved according to the standard protocol prions 2011 are no longer certified.

OneLife products are distributed internationally, including in Belgium, France, Germany, Holland, Luxembourg, Portugal, Italy, China, SE Asia and South Africa. Contact us if you would like to become a distributor!